a² Pharmaceutical
Active Ingredients

Natural Bioactives

Active Ingredients


The most potent peptide with efficacious healing and anti-ageing properties...

Oligopeptide-1/EGF is a single polypeptide chain containing 53 amino acids. It catalyzes the healing process by causing epidermal and epithelial cells to divide and grow. It is the most potent mitogenic agent in the skin, and the single most important substance for the development and maintenance of both the epidermis and dermis. Oligopeptide-1/EGF is a natural element in our body and it decreases significantly as we age. Due to its biological nature, once oligopeptide-1/EGF is applied topically, significant improvement in the quality of skin can be visualized.

Oligopeptide-1/EGF has been used successfully in clinical applications including treatment of superficial skin lesions such as acne, minor burns, ulcers and minor inflammatory conditions.



The ‘Anti-oxidant from the Ocean’. One of nature’s most powerful antioxidants with demonstrable results in enhancing skin elasticity and refining skin tone...

A powerful natural antioxidant extracted from the marine microalgae Haematococcus pluvialis, Astaxanthin is a red-pigmented carotenoid with 500X* and 10X more potent anti-oxidant capabilities than Vitamin E and beta carotene.

Astaxanthin protects skin cells from UV rays, free radicals and oxidative stress that are inducive to the symptoms of aging skin. It helps inhibit collagen degradation and is particularly effective on enhancing skin elasticity and hydration, lightening spots and reducing fine lines and wrinkles.

*Shimidzu N, Goto M, and Miki W. “Carotenoids as singlet oxygen quenchers in marine organisms.”
 Fisheries Science. 62(1):134-137.


Glycosaminoglycans (GAGs)

An epidermal ground substance and a very solid binder of protein, water and cellular elements, Glycosaminoglycans are essential to skin cells metabolism, and help increase dermal production of extracellular matrix components (ECM) such as collagen. They also promote the ability of collagen fibres to retain water and bind moisture into the stratum corneum of the epidermis, providing an effective water resource for skin.

This ingredient brings significant benefits to aged/damaged skin by smoothening scars, fine line and wrinkles and facilitating skin regeneration.


Hyaluronic Acid (HA)

An extremely effective hydrating source that binds water content in the extracellular matrix (ECM) to promote firmer skin and more even skin tone...

A chief component of the extracellular matrix (ECM), the fluid-filled space between cells, Hyaluronic acid encourages water retention in skin tissues. It locks moisture and collagen into the ECM, enabling skin to appear smoother and firmer.

For clinical applications, it also facilitates wound healing, and can reduce the appearance of both old and new scars.


Hydrolyzed Collagen

A hydrolyzed form of collagen in very small molecules with high concentration of amino acids. It helps strengthen skin architecture with enhanced elasticity, smoothness and plumpness.

Collagen accounts for one-fourth of all the proteins in the human body and is an important protein that gives the skin its youthful appearance and elasticity. Collagen Peptide is a controlled enzymatic break-down product of collagen-derived protein from about 300,000Da to an average molecular weight between 2000 and 5000Da. It contains 20 amino acids, predominantly Glycine, Proline and Hydroxyproline. The substance helps maintain collagen production and younger, firmer skin.

It has been used by doctors and hospitals for treating burns and other skin conditions.

Caprylic/Capric Triglyceride

Caprylic/Capric Triglyceride contains anti-bacterial functions and forms a skin barrier to prevent moisture loss, leaving skin surface with a smooth and soft touch.

Citric Acid

Citric acid can remove dead skin cells and facilitate new cell turnover, which helps alleviate symptoms of aging such as age spots, fine lines and wrinkles and uneven skin tone.


A ‘hydration magnet’ that keeps the skin moisturized and smooth. Apart from its water retention capabilities, Glycerin also helps strengthen other lipids of the intercellular layer for a healthier and more even skin structure


A class of chemical compounds of Vitamin E, Tocopherol is an effective antioxidant that protects skin against UV-induced damages and also alleviates inflammatory response of skin.


Urea is a natural moisturizer found within the skin. It is known for its anti-bacterial, anti-inflammatory and antimicrobial properties. It offers effective moisturization for skin and promotes skin cell regeneration.


Natural Bioactives

Canola Oil

Canola Oil contains Vitamin E that helps protect skin from damaging free radicals caused by UV rays and pollution. It also makes the skin smoother.


Clematis Vitalba Extract

Clematis Vitalba boosts metabolism of skin cells and promotes firmer and smoother skin.


Equisetum Arvense Extract

A botanical classification of horsetail, Equisetum Arvense is approved for treatment of wounds and burns. It contains oligoelements and minerals like silicium which contribute directly to the synthesis of collagen or proteoglycans and to the stabilization of the extracellular matrix (ECM).


Fucus Extract

A deep sea algae with strong antioxidant power, Fucus is rich in amino acids, minerals and vitamins and helps eliminate toxic materials and excess water for firmer and more radiant skin.


Hedera Helix Extract

A botanical classification of English Ivy, Hedera Helix has deep cleansing properties and boosts skin cell metabolism.


Humulus Lupulus Extract

A botanical classification of hops flower, Humulus Lupulus has a calming effect on skin and facilitates the healing of skin conditions such as itchiness, rashes and minor ulcers.


Kaninabara Fruit Extract

Kaninabara Fruit contains aromatherapeutic properties for a soothing and relaxing feel.


Lemon Fruit Extract

An astringent botanical and a natural detoxifying agent that contributes to the elimination of dead cells from the skin surface. Lemon Fruit keeps skin hydrated and facilitates skin cell renewal for healthier and brighter skin.


Leuconostoc/Radish Root Ferment Filtrate

Leuconostoc/Radish Root Ferment Filtrate is a natural ingredient originated from Japan with effective preservative properties.


Meadowsweet Extract

Also known as ‘Queen of the Meadow’, this herb contains anti-inflammatory effects and soothes irritated skin. It also helps tighten skin and promotes a brighter complexion.


Rice Bran Oil

Rich in Vitamin E, ceramides and glycosylceramides, Rice Bran Oil keeps skin hydrated, and helps protect skin from oxidative stress. It also prevents the accumulation of melanin.


Rosemary Leaf Extract

This medicinal botanical has antimicrobial, antiviral and antioxidant effects. It also facilitates blood circulation and has a curing and calming effect on skin.


Scot Pine Conifer Cone Extract

This ingredient contains antiseptic and anti-inflammatory properties.


Tuberose Polysaccharides

Tuberose Polysaccharides contain aromatherapeutic properties that leave skin smooth, moisturized and relaxed.


Wasabia Japonica Root Ferment Extract

Wasabia Japonica Root Ferment Extract is a natural ingredient originated from Japan with extremely powerful antioxidant and antimicrobial properties. It is highly efficacious in preventing premature ageing caused by free radicals and microbes, and has a soothing effect on skin.

    100% made in Japan